Strzelczyk AK, Paul TJ, Schmidt, S, Quantifying thermo-switchable carbohydrate mediated interactions via soft colloidal probe adhesion studies Macromolecular Bioscience 2020 accepted

Paul TJ, Strzelczyk AK, Feldhof, MI; Schmidt S, Temperature-Switchable Glycopolymers and Their Conformation-Dependent Binding to Receptor Targets. Biomacromolecules 2020 accepted

Rettke D., Döring J, Martin S., Venus T, Estrela-Lopis I., Schmidt S, Ostermann K, Pompe T, Picomolar glyphosate sensitivity of an optical particle-based sensor utilizing biomimetic interaction principles. Biosensors and Bioelectronics, 2020, 165, 112262.


Schmidt S, Paul T, Strzelczyk A, Interactive polymer gels as biomimetic sensors for carbohydrate interactions and capture-release devices for pathogens, Macromolecular Chemistry and Physics, 2019, 22, 1900323

Baer A, Oliveira IS, Schmidt S, Harrington MJ, Mayer G, Mechanismen der Natur als Vorbild für nachhaltige Biomaterialien: Einblicke in den „Sekundenkleber“ der Stummelfüßer. Biologie in unserer Zeit, 2019, 6, 418

Paul T, Rübel S, Hildebrandt M, Strzelczyk A, Spormann C, Lindhorst T, Schmidt S, Thermosensitive display of carbohydrate ligands on microgels for switchable binding of proteins and bacteria, ACS Applied Materials & Interfaces, 2019, 11, 26674

Baer A,  Schmidt S,  Mayer G, Harrington M, Fibers on the Fly: Multiscale Mechanisms of Fiber Formation in the Capture Slime of Velvet Worms. Integrative and Comparative Biology, 2019, icz048

Baer A, Horbelt N, Nijemeisland M, Garcia S, Fratzl P, Schmidt S, Mayer G, Harrington M, Shear-Induced Beta-Crystallite Unfolding in Condensed Phase Nanodroplets Promotes Fiber Formation in a Biological Adhesive, ACS Nano, 2019, 13 (5), 4992-5001.

Camaleño de la Calle A,  Gerke C, Chang XJ, Grafmüller A, Hartmann L, Schmidt S, Multivalent interactions of polyamide based sequence-controlled glycomacromolecules with concanavalin A, Macromolecular Bioscience 2019, 19 (6), e1900033.

Waschke J, Pompe T, Rettke D, Schmidt S, Hlawitschka M, Radial profile detection of multiple spherical particles in contact with interacting surfaces." PLOS ONE, 2019, 14(4): e0214815


Baer, A.; Hänsch, S.; Mayer, G.; Harrington, M.; Schmidt, S., Reversible supramolecular assembly of velvet worm adhesive fibers via electrostatic interactions of charged phosphoproteins, Biomacromolecules 2018, 19, 4034

Bucher, K. S.;  Yan, H.;  Creutznacher, R.;  Ruoff, K.;  Mallagaray, A.;  Grafmuller, A.;  Dirks, J. S.;  Kilic, T.;  Weickert, S.;  Rubailo, A.;  Drescher, M.;  Schmidt, S.;  Hansman, G.;  Peters, T.;  Uetrecht, C.; Hartmann, L., Fucose-Functionalized Precision Glycomacromolecules Targeting Human Norovirus Capsid Protein. Biomacromolecules 2018, 19, 3714.

Jacobi, F.;  Camaleño de la Calle, A.;  Boden, S.;  Grafmuller, A.;  Hartmann, L.; Schmidt, S., Multivalent Binding of Precision Glycooligomers on Soft Glycocalyx Mimicking Hydrogels. Biomacromolecules, 2018, 19 (8), 3479-3488.

Gerke, C.;  Jacobi, F.;  Goodwin, L. E.;  Pieper, F.;  Schmidt, S.; Hartmann, L., Sequence-Controlled High Molecular Weight Glyco(oligoamide)–PEG Multiblock Copolymers as Ligands and Inhibitors in Lectin Binding. Macromolecules, 2018, 51 (15), 5608

Madaboosi, N.; Uhlig, K.; Schmidt, S.; Vikulina, A. S.; Möhwald, H.; Duschl, C.; Volodkin, D., A “Cell-Friendly” Window for the Interaction of Cells with Hyaluronic Acid/Poly-l-Lysine Multilayers, Macromolecular Bioscience, 2018, 18, 1700319

Elshaarawy, R. F. M.;  Dechnik, J.;  Hassan, H. M. A.;  Dietrich, D.;  Betiha, M. A.;  Schmidt, S.; Janiak, C., Novel high throughput mixed matrix membranes embracing poly ionic liquid-grafted biopolymer: Fabrication, characterization, permeation and antifouling performance. Journal of Molecular Liquids, 2018, 266, 484-494.


Wang, H.; Jacobi, F.; Waschke, J.; Hartmann, L.; Lowen, H.; Schmidt, S., Elastic Modulus Dependence on the Specific Adhesion of Hydrogels, Advanced Functional Materials, 2017, 27, 1702040

Baer, A.; Schmidt, S.; Haensch, S.; Eder, M.; Mayer, G.; Harrington, M. J., Mechanoresponsive lipid-protein nanoglobules facilitate reversible fibre formation in velvet worm slime, Nature Communications, 2017, 8 (1), 974.

Strzelczyk, A. K.; Wang, H.; Lindhorst, A.; Waschke, J.; Pompe, T.; Kropf, C.; Luneau, B.; Schmidt, S., Hydrogel Microparticles as Sensors for Specific Adhesion: Case Studies on Antibody Detection and Soil Release Polymers, Gels, 2017, 3, 31

Sapudom, J.; Ullm, F.; Martin, S.; Kalbitzer, L.; Naab, J.; Moller, S.; Schnabelrauch, M.; Anderegg, U.; Schmidt, S.; Pompe, T., Molecular weight specific impact of soluble and immobilized hyaluronan on CD44 expressing melanoma cells in 3D collagen matrices, Acta Biomaterialia, 2017, 50, 259-270.

Diba, M.; Camargo, W. A.; Brindisi, M.; Farbod, K.; Klymov, A.; Schmidt, S.; Harrington, M. J.; Draghi, L.; Boccaccini, A. R.; Jansen, J. A.; van den Beucken, J. J. J. P.; Leeuwenburgh, S. C. G., Composite Colloidal Gels Made of Bisphosphonate-Functionalized Gelatin and Bioactive Glass Particles for Regeneration of Osteoporotic Bone Defects, Advanced Functional Materials, 2017, 27


Diba, M.; An, J.; Schmidt, S.; Hembury, M.; Ossipov, D.; Boccaccini, A. R.; Leeuwenburgh, S. C., Exploiting Bisphosphonate-Bioactive-Glass Interactions for the Development of Self-Healing and Bioactive Composite Hydrogels, Macromolecular Rapid Communications, 2016, 37, 1952-1959.

S. Martin, H. Wang, T. Rathke, U. Anderegg, S. Möller, M. Schnabelrauch, T. Pompe and S. Schmidt, Polymer hydrogel particles as biocompatible AFM probes to study CD44/hyaluronic acid interactions on cells, Polymer, 2016

K. Farbod, M. Diba, T. Zinkevich, S. Schmidt, M. J. Harrington, A. P. M. Kentgens and S. C. G. Leeuwenburgh, Gelatin Nanoparticles with Enhanced Affinity for Calcium Phosphates, Macromolecular Bioscience, 2016, 16, 717-729.


S. Schmidt, H. Wang, D. Pussak, S. Mosca and L. Hartmann, Quantification of protein-materials interaction by soft colloidal probe spectroscopy, Beilstein Journal of Organic Chemistry, 2015, 11, 720-729.

Martin S.; Wang H.; Hartmann L.; Pompe T.; Schmidt, S., Quantification of Protein-Materials Interaction by Soft Colloidal Probe Spectroscopy, Physical Chemistry Chemical Physics, 2015, 17, 3014-3018.


Glaubitz, M.; Medvedev, N.; Pussak, D.; Hartmann, L.; Schmidt, S.; Helm, C. A.; Delcea, M., A novel contact model for AFM indentation experiments on soft spherical cell-like particles. Soft Matter 2014, 10, (35), 6732-6741.

Pussak, D.; Ponader, D.; Mosca, S.; Pompe, T.; Hartmann, L.; Schmidt, S., Specific Adhesion of Carbohydrate Hydrogel Particles in Competition with Multivalent Inhibitors Evaluated by AFM, Langmuir 2014, 30, (21), 6142-615.

Schmidt, S.; Reinecke, A.; Wojcik, F.; Pussak, D.; Hartmann, L.; Harrington, M. J. Metal-Mediated Molecular Self-Healing in Histidine-Rich Mussel Peptides, Biomacromolecules 2014 , 15, (5), 1644-1652.

Schmidt, S.; Uhlig, K.; Duschl, C.; Volodkin, D., Stability and cell uptake of calcium carbonate templated insulin microparticles. Acta Biomaterialia 2014, 10, (3), 1423-1430.

Ponader, D.; Maffre, P.; Aretz, J.; Pussak, D.; Ninnemann, N. M.; Schmidt, S.; Seeberger, P. H.; Rademacher, C.; Nienhaus, G. U.; Hartmann, L., Carbohydrate-Lectin Recognition of Sequence-Defined Heteromultivalent Glycooligomers. Journal of the American Chemical Society 2014, 136, (5), 2008-2016.


Pussak, D.; Ponader, D.; Mosca, S.; Ruiz, S. V.; Hartmann, L.; Schmidt, S., Mechanical Carbohydrate Sensors Based on Soft Hydrogel Particles. Angewandte Chemie International Edition 2013, 52 (23), 6084-6087.

Behra, M.; Azzouz, N.; Schmidt, S.; Volodkin, D. V.; Mosca, S.; Chanana, M.; Seeberger, P. H.; Hartmann, L., Magnetic Porous Sugar-Functionalized PEG Microgels for Efficient Isolation and Removal of Bacteria from Solution. Biomacromolecules 2013, 14, (6), 1927-1935.

Schmidt, S.; Volodkin, D., Microparticulate biomolecules by mild CaCO3 templating, Journal of Materials Chemistry 2013, (1), 1210-1218.

Schmidt, S.; Behra, M.; Uhlig, K.; Madaboosi, N.; Hartmann, L.; Duschl, C.; Volodkin, D., Mesoporous Protein Particles Through Colloidal CaCO3 Templates. Advanced Functional Materials 2013, 23 (1), 116-123.

Palankar R.; Pinchasik B.-E.; Fernandes PLA.; Schmidt, S.; De Geest BG.; Fery A.; Möhwald H.; Skirtach AG.; Delcea M.; Mechanical strength and intracellular uptake of CaCO3 - templated LbL capsules composed of bio-degradable polyelectrolytes: the influence of the number of layers, Journal of Materials Chemistry 2013, 1, 1175-1181.


Uhlig, K.; Madaboosi, N.; Schmidt, S.; Jager, M. S.; Rose, J.; Duschl, C.; Volodkin, D. V., 3d localization and diffusion of proteins in polyelectrolyte multilayers. Soft Matter 2012, 8 (47), 11786-11789.

Schmidt, S.; Madaboosi, N.; Uhlig, K.; Köhler, D.; Skirtach, A.; Duschl, C.; Möhwald, H.; Volodkin, D. V., Control of Cell Adhesion by Mechanical Reinforcement of Soft Polyelectrolyte Films with Nanoparticles. Langmuir 2012, 28, (18), 7249-7257.

Behra, M.; Schmidt, S.; Hartmann, J.; Volodkin, D. V.; Hartmann, L., Synthesis of Porous PEG Microgels Using CaCO3 Microspheres as Hard Templates. Macromolecular Rapid Communications 2012, 33, (12), 1049-1054.

Madaboosi, N.; Uhlig, K.; Schmidt, S.; Jager, M. S.; Mohwald, H.; Duschl, C.; Volodkin, D. V., Microfluidics meets soft layer-by-layer films: selective cell growth in 3D polymer architectures. Lab on Chip 2012, 12, (8), 1434-1436.

Kohler, D.; Madaboosi, N.; Delcea, M.; Schmidt, S.; De Geest, B. G.; Volodkin, D. V.; Möhwald, H.; Skirtach, A. G., Patchiness of Embedded Particles and Film Stiffness Control Through Concentration of Gold Nanoparticles. Advanced Materials 2012, 24 (8), 1095-1100.

Volodkin, D. V.; Schmidt, S.; Fernandes, P.; Larionova, N. I.; Sukhorukov, G. B.; Duschl, C.; Möhwald, H.; von Klitzing, R., One-Step Formulation of Protein Microparticles with Tailored Properties: Hard Templating at Soft Conditions. Advanced Functional Materials 2012, 22, (9), 1914-1922.

Pussak, D.; Behra, M.; Schmidt, S.; Hartmann, L., Synthesis and functionalization of poly(ethylene glycol) microparticles as soft colloidal probes for adhesion energy measurements. Soft Matter 2012, 8, (5), 1664-1672.


Schmidt, S.; Fernandes, P. A. L.; De Geest, B. G.; Delcea, M.; Skirtach, A. G.; Mohwald, H.; Fery, A., Release Properties of Pressurized Microgel Templated Capsules. Advanced Functional Materials 2011, 21 (8), 1411-1418.

Delcea, M.; Schmidt, S.; Palankar, R.; Fernandes, P. A. L.; Fery, A.; Möhwald, H.; Skirtach, A. G., Mechanobiology: Correlation Between Mechanical Stability of Microcapsules Studied by AFM and Impact of Cell-Induced Stresses. Small 2011,  6, (24), 2858-2862.

Gentsch, R.; Pippig, F.; Schmidt, S.; Cernoch, P.; Polleux, J.; Börner, H. G., Single-Step Electrospinning to Bioactive Polymer Nanofibers. Macromolecules 2011, 44 (3), 453-46.

2010 and before

Schmidt, S.; Zeiser, M.; Hellweg, T.; Duschl, C.; Fery, A.; Mohwald, H., Adhesion and Mechanical Properties of PNIPAM Microgel Films and Their Potential Use as Switchable Cell Culture Substrates. Advanced Functional Materials 2010, 20 (19), 3235-324.

Fernandes, P. A. L.; Schmidt, S.; Zeiser, M.; Fery, A.; Hellweg, T., Swelling and mechanical properties of polymer gels with cross-linking gradient. Soft Matter 2010, 6, (15), 3455-3458.

Schmidt, S.; Kessel, S.; Wischerhoff, E.; Laschewsky, A.; Lutz, J. F.; Uhlig, K.; Lankenau, A.; Duschl, C.; Fery, A., Bioactive Surfaces Based on PEG Brushes. Imaging and Microscopy 2010, 1/2010.

Kessel, S.; Schmidt, S.; Muller, R.; Wischerhoff, E.; Laschewsky, A.; Lutz, J. F.; Uhlig, K.; Lankenau, A.; Duschl, C.; Fery, A., Thermoresponsive PEG-Based Polymer Layers: Surface Characterization with AFM Force Measurements. Langmuir 2010, 26, (5), 3462-3467.

Erath, J.; Schmidt, S.; Fery, A., Characterization of adhesion phenomena and contact of surfaces by soft colloidal probe AFM. Soft Matter 2010, 6, (7), 1432-1437.

Kluge, D.; Abraham, F.; Schmidt, S.; Schmidt, H. W.; Fery, A., Nanomechanical Properties of Supramolecular Self-Assembled Whiskers Determined by AFM Force Mapping. Langmuir 2010, 26, (5), 3020-3023.

Schmidt, S.; Helfer, E.; Carlier, M. F.; Fery, A., Force Generation of Curved Actin Gels Characterized by Combined AFM–Epifluorescence Measurements. Biophysical Journal 2010, 98, 2246-2253.

Romet-Lemonne, G.; Helfer, E.; Delatour, V.; Bugyi, B.; Bosch, M.; Romero, S.; Carlier, M.-F.; Schmidt, S.; Fery, A., Biomimetic Systems Shed Light on Actin-Based Motility Down to the Molecular Scale. Biophysical Reviews and Letters 2009, 4, (1-2), 5-15.

Altstädt, V.; Lovera, D.; Schmidt, H.-W.; Schmidt, S.; Fery, A., Electrospun Polymeric Fine Fibres. Imaging and Microscopy 2008, 2/2008, (2), 29-31. 

Schmidt, S.; Van der Gucht, J.; Biesheuvel, P. M.; Weinkamer, R.; Helfer, E.; Fery, A., Non-Gaussian curvature distribution of actin-propelled biomimetic colloid trajectories. European Biophysics Journal with Biophysics Letters 2008, 37, (8), 1361-1366.

Schmidt, S.; Motschmann, H.; Hellweg, T.; von Klitzing, R., Thermoresponsive surfaces by spin-coating of PNIPAM-co-PAA microgels: A combined AFM and ellipsometry study. Polymer 2008, 49, (3), 749-756.

Schmidt, S.; Hellweg, T.; Klitzing, R., Packing Density Control in P(NIPAM-co-AAc) Microgel Monolayers: Effect of Surface Charge, pH, and Preparation Technique. Langmuir 2008, 24, 12595-12602.

Schmidt, S.; Nolte, M.; Fery, A., Single-colloidal-particle microcontact printing. Physical Chemistry Chemical Physics 2007, 9, (36), 4967-4969. 



Schmidt, S.; Hartman, L.; Pussak, D.; Pompe, T.; “Label-free method for the detection of analytes based on soft hydrogel particles “International application Nr.: PCT / EP 2014 / 050163

Wischerhoff, E.; Laschewsky, A.; Schmidt, S.; Lankenau, A.; Lutz, J. F.; Lankenau, A.; Duschl, C.; „Thermoresponsives Multischichtsubstrat für biologische Zellen“ European application Nr.: EP2390310

Schmidt, S.; Duschl, C.; Lankenau, A.; Wischerhoff, E.; Lutz, J. F; Laschewsky, A.; “Thermoreactive Substrate with microgels, method for its preparation, and culture method for biological cells”, International application Nr.: PCT/EP2011/001394

Grinberg, A; Skirtach, A; Volodkin, D. V.; Möhwald, H; Schmidt, S.; Klitzing, R. v.; “Synthesizing particles/capsules for encapsulating bio-molecules including polymers, proteins, peptides, insulin, oligonucleotides, cytokines and medicine, involves lowering pH during particle or capsule fabrication”, Patent Nr.: US2012094008-A1


Further Publications

·         Scientific video for Beilstein TV:


Verantwortlich für den Inhalt: E-Mail sendenStephan Schmidt